Sodium azide is a common preservative of samples and stock solutions in laboratories and a useful reagent in synthetic work. Two crystalline forms are known, rhombohedral and hexagonal. Sodium azide is a rapidly acting, potentially deadly chemical that exists as an odorless white solid. Sodium azide hazards and disposal university of nebraska. Sodium azide, 1% wv, aqueous solution, common lab preservative. General information and product description the antibodies supplied by atlas antibodies, are delivered in a mixture constituting 40% glycerol, pbs ph 7.
Flush with large amounts of water to prevent azide buildup in plumbing. However, few details of these cases and their investigations have been reported previously. Sodium azide poisoning at a restaurant dallas county, texas. It also changes into a toxic gas hydrazoic acid when it comes in contact with solid metals for examp. Contains human serum or other human source material. If medical attention is not available on the worksite or surroundings send the patient to a hospital together with a copy of the msds. It is often a better choice for this purpose than thimerosal, as sodium azide does not contain mercury. Sodium azide warning very dangerous, take precautions to make a 10% stock solution of sodium azide, dissolve 10 g of sodium azide in 100 ml of distilled h 2 o.
What is the purpose of adding sodium azide to buffers. Sodium azide is a reagent used in the production of compounds which incorporate nitrogen in their structure, including pharmaceuticals and propellants. Workers should wash hands and face before eating, drinking and smoking. It is used for the preparation of other azide compounds.
Sodium azide is commonly used as a bacteriostatic preservative for biological samples and also as a source to generate gas in automobile airbags. Sodium azide hazards and disposal sodium azide is used at uno in the preservation of samples and stock solutions. You have selected the maximum number of product attributes 3 to compare. Safety data sheet ra latex test kit date of first issue. Material safety data sheet sodium sulfate anhydrous. Sodium azide material safety data sheet cas no 26628228. Uses advised against food, drug, pesticide or biocidal product use. American azide is the sole north american manufacturer of sodium azide, a chemical with uses as an intermediate in the pharmaceutical industry as well as other applications. A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. Use the product attributes below to configure the comparison table. Firstaid measures general advice show this safety data sheet to the doctor in attendance. Sodium azide is converted rapidly into hydrazoic acid vapor upon contact with water or an acid. Material safety datasheet for sodium azide naaz identification of the substance preparation and of the company undertaking product name sodium azide preparation lyophilised or reconstituted with water buffer at a concentration of no greater than 0.
In hospitals and laboratories, it is used as a biocide in bulk reagents and stock solutions to prohibit bacterial growth. When it is mixed with water or an acid, sodium azide changes rapidly to a toxic gas with a pungent sharp odor. Material safety data sheet sodium azide msds section 1. Information in this sds is from available published sources and is believed to be accurate. It also changes into a toxic gas hydrazoic acid when it comes in contact with solid metals for example, when it is poured into a. Sodium azide nan3, a common bactericide, pesticide and industrial nitrogen gas generator is known to be highly mutagenic in several organisms including plants and animals. This is a semipermeable membrane available in a wide range of size dimensions and pore sizes. American azide began producing sodium azide at american pacifics southern utah manufacturing facilities in 1993. View indentification, hazards, safety information, toxicity, regulations. Safety data sheet creation date 03dec2010 revision date 25apr2019 revision number 8 1.
The vapor of hydrazoic acid may be present where sodium azide is handled. Sodium azide revision 1 revision date 0804 2015 12. It is highly toxic and presents a severe explosion risk when shocked or heated. Sodium azide poisoning at a restaurant dallas county. Niosh recommended exposure limits potential for dermal absorption c 0. Material safety data sheet msds30701 revision d may 2010 page 1 of 8 identification of product and supplier 1. The user must determine suitability of this information for his. The products listed on this msds contain sodium azide, a chemical highly toxic in pure form.
This material safety data sheet is applicable to products containing sodium azide as preservative. At product concentrations, though not classified as hazardous, concentration buildups of sodium azide may react with lead and copper plumbing to form highly explosive metal oxides. Download msds material safety data sheet of sodium azide 10%. It is an ionic substance, is highly soluble in water, and is very acutely toxic. Nausea, headache, vomiting, laboratory experiments in animals have shown sodium azide to produce a profound hypotensive effect, demyelination of myelinated nerve fibers in the central nervous system, testicular damage, blindness, attacks of rigidity, and hepatic and cerebral effects. Eye contact in the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Ingestion of sodium azide has been reported to cause shortness of breath, nausea, vomiting, restlessness, diarrhea, lowering of blood pressure hypotension and. Sodium azide is a white powder that explodes when it hits metal. Handling and storage advice on general occupational hygiene conditions for safe storage, including any incompatibilities eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. No warranty, express or implied, is made and labchem inc assumes. Like sodium azide, hydrozoic acid is highly explosive. No sop is required if a lab has only premade kits where sodium azide is present as a preservative at 1% concentration or less.
The azide anion is very similar in each form, being centrosymmetric with nn distances of 1. Sodium azide is a useful probe reagent, mutagen, and preservative. Please note that if the azide is not included the buffer will not be as stabl. Information sheet cis on sodium azide must always be kept in the immediate work area where it is used, along with a material safety data sheet msds on sodium azide. Material safety data sheet for reagents containing sodium azide. Derivatives of pyrano3,2cazepines 2 and isomeric pyrano3,2bazepines 3 were isolated by the application of trimethylsilyl azide or sodium azide in a methylene chloride or a chloroform. When it hits water, it turns into an acid that can eat through your skin. Sodium azide definition of sodium azide by medical dictionary. Substance name sodium azide casrn 26628228 last revised 03311987 the oral reference dose rfd is based on the assumption that thresholds exist for certain toxic effects such as cellular necrosis. General information the osha hazard communications standard cfr 1910. The tpq does not default to 0 pounds for nonpowder, nonmolten, nonsolution form 15. Ingestion is an important route of exposure to solid sodium azide. It can be excluded from the buffer without affecting the performance of the assay. The sodium azide is a preservative preventing the microbial growth in the buffer.
Dialysis a dialysis unit can be used to remove sodium azide from samples of 0. The use of the 1% solution is convenient and minimizes exposure and contamination risks normally encountered while handling sodium azide powder. Orl mus ld50 27 mgkg orl rat ld50 27 mgkg skn rat ld50 50 mgkg. Work being done with sodium azide must be performed in a chemical fume hood. S227i500lc casno 26628228 synonyms sodium salt of hydrazoic acid. This colorless salt is the gasforming component in many car airbag systems. Sodium azide is the nastiest chemical that ever saved lives.
Harmful to aquatic life in very low concentrations. When mixed with water or an acid, or comes in contact with a solid metal it changes rapidly to form a toxic gas with a pungent odor. It is soluble in water or liquid ammonia, slightly soluble in alcohols, and insoluble in ether. Sodium azide can be absorbed into the body by inhalation, ingestion, skin contact, or eye contact. Material safety data sheet for reagents containing sodium. Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Sodium azide, nan3 synonyms azide, azium, sodium salt of hydrazoic acid cas number 26628 22 8 molecular weight 65. Uses advised against food, drug, pesticide or biocidal product use details of the supplier of the safety data sheet emergency telephone number. Sodium azide is the inorganic compound with the formula nan 3.
If sodium azide is released into the air as fine particles aerosol, it has the potential to contaminate agricultural products. Sodium azide definition of sodium azide by medical. Keep container sizes and quantities in work area as small as possible. Nan 3 microbiology a toxic salt addedconcentration, 0. Sodium azide is a toxic chemical used widely in industry that has been added to beverages, either intentionally or unintentionally, in foodborne poisoning incidents in the united states and japan.
Symptoms of acute exposure to hydrazoic acid include eye irritation, headache. Sigmaaldrich offers a number of sodium azide products. The following three procedures can be used to remove sodium azide. Further action will be the responsibility of the medical specialist. Sodium azide substance sodium azide hydrazoic acid, sodium salt cas 26628228 formula nan 3 physical properties colorless crystalline solid mp 275 c decomposes readily soluble in water 41. Sodium azide nan3 is a colorless crystalline solid and is readily soluble in water. Sodium azide uses, dmf, dossier, manufacturer, supplier. Azide ingestions are potentially dangerous to health care providers.
Superfund amendments and reauthorization act sara 302 extremely hazardous substances. Ingestion of sodium azide has been reported to cause shortness of breath, nausea, vomiting, restlessness, diarrhea, lowering of blood pressure hypotension and collapse. Sds of sodium azide, safety data sheets, cas 26628228. Must sodium azide be added to buffers when prepared by the user. Chemical product and company identification product name. Over a period of time, sodium azide may react with copper, lead, brass, or solder in plumbing systems to form an accumulation of the highly explosive compounds of lead azide and copper azide. It is also a metabolic inhibitor, which inhibits oxidative phosphorylation. A 1% aqueous solution of sodium azide 154mm for use as a preservative for laboratory reagents.
Similar to cyanide, sodium azide and hydrozoic acid also interfere with cellular respiration and aerobic metabolism, preventing the cells from using oxygen. Material safety data sheet for reagents containing sodium azide in accordance with ue 4532010 y ce 12722008 revision date. Postive markers contains sodium azide, foxp3transcription factor concentrate 4 contains 14% formaldehyde and msds 004 rev 1 august 2014 page 4 of 5 ingestion. Addition of water to sodium azide which was heated caused a violent reaction. Due to the hazards associated with solid sodium azide, buying dilute solutions of 5% or less sodium azide is recommended. Photolysis of sodium azide may result in metal nitrides initially, with the eventual formation of the free metal and nitrogen gas.
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